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Silicon Dioxide Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Effects of Silicon Dioxide on Weight Reduction

Authors: Marcus Free MD, Rouzbeh Motiei-Langroudi MD, Waqar Ahmad PhD, Kelly Daly RDN, and Don Juravin (Don Karl Juravin).

Abstract (Research Summary)

  • Silicon dioxide (aka silica) reduces body weight and fat composition in animals (Kupferschmidt 2014).
  • Silicon dioxide can improve metabolism and burn additional calories (Martin 2007).
  • Silicon dioxide prevents the development of spontaneous diabetes in rats possibly through blocking the destruction of pancreatic beta cells (Papaccio 1991, Oschilewski 1986, Oschilewski 1985).

Silicon Dioxide Effects on Weight Reduction

Silicon dioxide improves metabolism and calorie burning in humans resulting in weight reduction.

  • Silicon dioxide can improve metabolism and burn more calories (Martin 2007).
  • Silicon dioxide reduces brown adipocyte differentiation and brown adipocyte-specific genes (Son 2015). Repressing brown adipocytes may have beneficial anti-obesity effects.
  • Silicon dioxide reduces body weight and fat composition in animals receiving a high-fat diet (Kupferschmidt 2014).

Silicon Dioxide Effects on Diabetes

Silicon Dioxide prevents the development of spontaneous diabetes in rats, possibly through enhancing host mechanisms effective in preventing the destruction of pancreatic beta cells.

  • Silicon dioxide prevents the development of spontaneous diabetes in rats, possibly through blocking the detrimental effects of macrophages on pancreatic beta cells (Oschilewski 1986, Oschilewski 1985).
  • Silicon dioxide prevents the development of diabetes in rats through enhancing host mechanisms effective in preventing the destruction of pancreatic beta cells (Papaccio 1991).

Safety, Side Effects, Drug Interactions

Safety

Silicon dioxide is Generally Recognised As Safe (GRAS) according to the FDA.

Side effects

Silicon dioxide has currently no known side effects.

Drug interactions

Silicon dioxide has currently no known drug interactions.

Caution

  • Pregnancy and breastfeeding: There is limited research and therefore best to avoid Silicone dioxide during pregnancy or breastfeeding.

References

  1. Kupferschmidt, N., Csikasz, R., Ballell, L., et al. (2014). Large pore mesoporous silica induced weight loss in obese mice. Nanomedicine [online], 9 (9), pp.1353-62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24471500 [Accessed 10.06.2016].
  2. Martin, K. (2007). The chemistry of silica and its potential health benefits. The Journal of Nutrition, Health & Aging [online], 11 (2), pp: 94-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17435951 [Accessed 10.06.2016].
  3. Oschilewski, U., Kiesel, U., Kolb, H. (1985). Administration of silica prevents diabetes in BB-rats. Diabetes [online], 34 (2), pp. 197-9. Available from:
    http://www.ncbi.nlm.nih.gov/pubmed/2981751 [Accessed 07.06.2016].
  4. Oschilewski, M., Schwab, E., Kiesel, U., et al. (1986). Administration of silica or monoclonal antibody to Thy-1 prevents low-dose streptozotocin-induced diabetes in mice. Immunology Letters [online], 12 (5-6), pp. 289-94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3015785 [Accessed 07.06.2016].
  5. Papaccio, G., Frascatore, S., Esposito, V., et al. (1991). Early macrophage infiltration in mice treated with low-dose streptozocin decreases islet superoxide dismutase levels: prevention by silica pretreatment. Acta Anatomica (Basel). 142 (2), pp. 141-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1664165 [Accessed 07.06.2016]. 
  6. Son, M., Kim, W., Kwak, M., et al. (2015). Silica nanoparticles inhibit brown adipocyte differentiation via regulation of p38 phosphorylation. Nanotechnology [online], 26 (43), pp. 435101. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26437254 [Accessed 11.06.2016].

Footnote

This research was sponsored by GLOBESITY FOUNDATION (nonprofit organization) and managed by Don Juravin. GLOBESITY Bootcamp for the obese is part of GLOBESITY FOUNDATION which helps obese with 70 to 400 lbs excess fat to adopt a healthy lifestyle and thereby achieve a healthy weight.

Tags: silicon dioxide, weight reduction, GLOBESITY FOUNDATION, weight loss, cravings, diabetes, healthy weight