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Doctors, Dietitions, and Health Professionals

We built the most comprehensive scientific library of weight reduction, cravings and diabetes research for health professionals.
Effects of Sugar Balancing on Weight Reduction, Cravings and Diabetes

Sugar Balancing Effects on Weight Reduction and Diabetes in GLOBESITY Bootcamp for the Obese

A new ‘yellow’ pill is introduced by our lab which has blood glucose-lowering benefits. Its ingredients include Banaba leaf extract, Bilberry fruit extract, Bitter melon fruit extract, Cinnamon bark extract, Chromium, Fenugreek seed extract, Gymnema Sylvestre leaf extract, Jambolan fruit extract, Pterocarpus marsupium bark extract, Tinospora Cordifolia leaf extract, Vanadyl sulfate, and Zinc.

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Effects of Propionate on Weight Reduction Cravings and Diabetes

Propionate Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Propionate produced in the gut as a result of bacterial fermentation reduces energy intake and appetite, regulates adipogenesis, and reduces adipose tissue inflammation, finally resulting in weight loss.
Propionate produced in the gut as a result of bacterial fermentation reduces cravings for carbohydrates.
Propionate produced in the gut as a result of bacterial fermentation increases insulin and insulin sensitivity, resulting in prevention and better control of diabetes.

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Effects of Vitamin C on Weight Reduction Cravings and Diabetes

Vitamin C Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Vitamin C decreases weight by increasing fat metabolism by 30% and reducing the inflammation of adipocytes. Vitamin C also increases the concentration of adiponectin, leptin, and insulin sensitivity.
Vitamin C decreases cravings by improving glycemic control and repairing and protecting brain centers responsible for serotonin and leptin sensitivity.
Vitamin C improves diabetes control by improving insulin sensitivity, glycemic control, oxidative stress, and immune responses.

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Effects of L-Tryptophan on Weight Reduction

L-Tryptophan Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

L-Tryptophan, acting via serotonergic neurons in hypothalamic feeding center, alters satiety and food preference, decreases carbohydrate cravings, carbohydrate intake, and daily energy intake, and promotes weight loss.
L-Tryptophan, either endogenous or exogenous, decreases craving. Tryptophan levels are reduced in obese individuals (by 18-25%) and dietary tryptophan administration suppresses carbohydrate craving (by 40%).
L-Tryptophan increases insulin and incretins secretion. The effect results in better glycemic control in diabetics.

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Effects of Cayenne Pepper on Weight Reduction

Cayenne Pepper Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp

Cayenne pepper significantly reduces weight (by 2%) and fat mass (by 7.8%) by increasing energy expenditure (by 13%) and decreasing ad libitum food intake resulting in ~960 calorie deficit per day. In an average 118 kg (260 lb) client, this is 2.4 kg (5.3 lbs) weight loss, 9.2 kg (20 lbs) fat loss, and 4 kg (8.8 lbs) increase in lean mass.
Cayenne pepper reduces cravings by 13.9% as a result of improved glycaemic control and reduced ghrelin levels.
Cayenne pepper reduces postprandial blood glucose levels by 10% resulting in improved glucose control and decreased risk of long-term complications.

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Effects of Citrus Aurantium on Weight Reduction

Citrus Aurantium Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Citrus aurantium decreases weight by up to 2.4 kg (5.3 lbs) in 1 week. Citrus aurantium increases the overall metabolism of fats and lipids by increasing epinephrine stimulation and increases the thermic effect of food by 29% in women.
Citrus aurantium decreases cravings by increasing the synthesis of insulin and dopamine, improving insulin sensitivity, suppressing ghrelin synthesis, protecting the liver from oxidative stress, and decreasing depression and anxiety.
Citrus aurantium improves insulin sensitivity and its synthesis by decreasing proliferation of adipocytes and fat accumulation. It also protects the liver from oxidative stress thus improving its ability to metabolize glucose.

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Clinical Research on Cravings in GLOBESITY Bootcamp for the Obese

Supporting Clinical Research on Cravings in GLOBESITY Bootcamp for the Obese

Obesity is caused by overeating, consuming unhealthy food, and satisfying cravings. We propose that while overeating is strongly linked to emotions and consuming unhealthy food relates to poor education, cravings are a medical condition responsible for the majority of unnecessary calories. Cravings differ from hunger in that hunger can be postponed, whereas cravings require immediate satisfaction for a specific substance such as sugar or fat (e.g. cakes, burgers, ice cream). Research proves that cravings are caused by the imbalance of gut flora, blood glucose levels, brain chemicals (mainly neurotransmitters), and five specific hormones (ghrelin, dopamine, epinephrine, norepinephrine, and serotonin).

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Sweeteners Effect on Weight Reduction, Diabetes and Cravings in GLOBESITY Bootcamp for the Obese

Effects of Sweeteners on Weight Loss, Cravings, and Diabetes

Sugar is made from equal parts of fructose and glucose. Almost all sugars and sweeteners activate the brain reward system, but to different extents. For instance,  fructose consumption is accompanied by a higher activity rise in the brain reward system and less satiety inducing. The effect is seen to a relatively less extent in glucose, saccharin, and sucralose.

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Weight Loss Surgeries Compared by Don Juravin

Weight Loss Surgeries Comparison

180,000 bariatric surgeries are completed every year, in America alone. The five most common bariatric surgeries include gastric bypass surgery, laparoscopic gastric band (aka Lap band), sleeve gastrectomy (aka Gastric sleeve), sleeve gastrectomy with duodenal switch, and vertical banded gastroplasty (aka Stomach stapling). 

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Digestive System Of The Obese Vs. Non-Obese

Digestive System Of The Obese Vs. Non-Obese

Obesity results from increased energy intake and decreased energy expenditure. The digestive (aka gastrointestinal or GI) system has a key role in the pathogenesis of obesity. Changes in digestive system hormones, digestive tract structure and motility and the inhibition of mechanisms that restrict calorie intake result in weight gain. However, It is not clear if digestive system changes cause or are affected by obesity (Acosta 2014).

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Raising Serotonin Naturally without Calories - RESEARCH

Raising Serotonin Naturally without Calories

Elevated brain serotonin levels are necessary for some human functions including elevated ‘happy’ mood and reduced weights. Besides pharmacological interventions that can increase serotonin levels and are therefore useful in the treatment and control of disorders like depression, anxiety, and possibly obesity, there are some non-pharmacologic ‘natural’ ways to increase brain serotonin levels, elevate mood, decrease anxiety and as a result, control appetite and promote weight loss.

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Don JURAVIN's New BMI vs. Very Old BMI

New BMI vs. Old BMI: Is It Time to Revise BMI?

The new calculations are based on the results of many researches regarding variations in body composition in different races, genders, and ages. The highlights from the researches are reviewed here. Based on these, a mathematical average has been calculated for each factor and the change in body density due to changes in body composition has been deduced.

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Red Meat Effect on Weight Reduction, Diabetes and Cravings in GLOBESITY Bootcamp for the Obese

Effects of Red Meat on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

The common definition considers red meat as a meat with a darker color before and after cooking. However, in nutrition, red meat is defined as any meat that has more myoglobin than white meat. Red meat is defined as all meats obtained from mammals (regardless of cut or age) as they have more myoglobin (United States Department of Agriculture). This includes beef, veal, lamb, pork, and also a leg of chicken and turkey (the latter are considered white by common definition). Fish and poultry (excluding legs) are considered white meat.

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STOPPING TO EAT 4 hours before bedtime

No Calories 4 Hours Before Sleep Effects on Weight Reduction in GLOBESITY Bootcamp Regimen

Post-dinner snacking leads to weight gain through the increased caloric intake (Waller, 2004). Nocturnal snacking increases sugar levels. When sugar levels are increased, hormones such as insulin, ghrelin, and leptin, are activated and specific systems in the body begin to work  (Kalergis, 2003). As the body becomes more alert through glucose metabolism, it may be difficult to switch off and fall asleep (Kristen, 2007). As shown in our other document, inadequate sleep causes weight gain. Women and men consume 15.3% and 9.2% more calories when deprived of sleep, respectively (St-Onge, 2011).

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Effects of  Salix Alba. L (White Willow Bark) on Weight Reduction

Salix Alba. L Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Salicin decreases weight by inhibiting the inflammation of adipocytes and increasing the release of fatty acids.
Salicin reduces cravings by improving glycemic control and increasing the concentration of tryptophan and serotonin released from the brain.
Salicin increases the secretion and sensitivity of insulin and protects the pancreas from inflammatory actions resulting in better glycemic control.

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Effects of 5-HTP on Weight Reduction

5-HTP Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

5-HTP (750mg to 900mg per day) increases satiety and decreases carbohydrate and food intake, promoting weight loss.
Serotonin decrease in the brain induces craving for carbohydrates and 5-HTP prevents craving.
Brain tryptophan is decreased in diabetic patients. Although 5-HTP is not shown to decrease blood glucose in diabetics in human studies, it has other beneficial effects in these patients including weight loss.

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Effects of Magnesium on Weight Reduction

Magnesium Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Magnesium supplementation in obese patients promotes weight loss and prevents complications of weight-loss regimens. 
Magnesium supplementation reduces cravings as a result of improved glucose control and increased synthesis and sensitivity of serotonin. 
Decreased magnesium levels increase the risk of diabetes. In contrast, magnesium supplementation in diabetic patients decreases fasting plasma glucose, HbA1c, and weight and therefore helps to control diabetes.

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Effects of Green Camellia Sinensis on Weight Reduction

Green Camellia Sinensis Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Green Camellia Sinensis decreases body weight (by 4.6%), abdominal fat (by 7.7%), and waist circumference (by 4.5%) as a result of increased thermogenesis and fat oxidation.
Green Camellia Sinensis decreases cravings by improving insulin sensitivity and glucose metabolism, protecting brain centers sensitive to dopamine and serotonin from oxidative stress and stabilizing mood. 
Green Camellia Sinensis decreases the risk of diabetes (by 33%) by reducing HbA1C levels, improving glucose metabolism, and increasing insulin sensitivity by 13%.

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Effects of L-Tyrosine on Weight Reduction

L-Tyrosine Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

L-Tyrosine is a precursor for dopamine and norepinephrine, which may help to promote weight loss through increased body activity and thermogenesis and decreased appetite.
Tyrosine (aka 4-hydroxyphenylalanine) is a non-essential amino acid used in the synthesis of certain neurotransmitters including dopamine, norepinephrine and epinephrine, as well as thyroid hormones thyroxine and triiodothyronine (Rosebrough 1994).

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Effects of Higenamine on Weight Reduction

Higenamine Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Higenamine stimulates fat burning and energy expenditure and reduces energy absorption by slowing gastric motility, resulting in weight loss and a healthier body fat ratio.
Higenamine decreases hormones involved with hunger and cravings such as dopamine, ghrelin, and neuropeptide.
Higenamine improves insulin secretion and sensitivity and blood glucose levels and benefits diabetics by increasing the glucose uptake into cells by up to 200%. 

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Effects of Naringin on Weight Reduction

Naringin Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Naringin decreases weight by increasing fat metabolism, decreasing inflammation of adipocytes, reducing hunger, and protecting the liver from oxidative stress. 
Naringin decreases cravings by normalizing blood glucose levels, reducing the secretion of ghrelin, and decreasing the sensitivity of brain centers to dopamine and serotonin. 
Naringin improves glycemic control by protecting the liver from oxidative stress, improving glucose metabolism in the liver, improving glucose uptake from the blood, enhancing the secretion of insulin from the pancreas, and reducing insulin resistance. 

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Effects of Yohimbine on Weight Reduction, Craving and Diabetes

Yohimbine Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Yohimbine is found naturally in the Pausinystalia Yohimbe tree and the Rauwolfia family of plants (Singh 2004). Yohimbine is best known for its fat burning and appetite suppressing properties.
Yohimbine (10mg twice daily) reduces fat percentage by 2.1% over three weeks (Ostojic 2006). In an individual with an average 45 kg (100 lb) overweight, this is 17 kg (37.5 lbs) fat reduction per year before any further dietary or exercise changes.
Yohimbine suppresses appetite and reduces food intake by 38% to 44% (Callahan 1984).

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Effects of Vitamin D on Weight Reduction

Vitamin D Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Vitamin D supplementation causes weight loss of up to 12.3 lbs (5.6 kg) in 2 years. Vitamin D status is inversely associated with total body fat percentage, BMI, waist circumference, and skinfolds. 
Vitamin D deficiency is associated with increased cravings for fatty foods. Vitamin D decreases cravings by increasing the ratio of healthy to unhealthy gut flora and protecting brain centers sensitive to serotonin and dopamine. 
Vitamin D deficiency decreases insulin secretion by 48%, disturbs glycemic control, and increases insulin resistance. Vitamin D supplementation improves the secretion of insulin from the pancreas. 

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Effects of Vitamin B6 on Weight Reduction, Craving and Diabetes

Vitamin B6 Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Vitamin B6 (Pyridoxine) is a water-soluble vitamin, which is best obtained from beans, poultry, fish, and dark leafy greens. Vitamin B6 is significant to protein, fat, and carbohydrate metabolism and the creation of red blood cells. It regulates mood and reduces stress by promoting neurotransmitters (serotonin, dopamine, gamma-aminobutyric acid) production, which in turn decreases cravings, preventing emotional eating, and weight gain. It is also important for thought processing and healthy brain development. Vitamin B6 enhances insulin’s effect on blood glucose and glycemic index in diabetes, which leads to higher glucose-lowering potency and better glucose control.

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Effects of Vitamin B12 on Weight Reduction, Craving and Diabetes

Vitamin B12 Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Vitamin B12 (Cobalamin) is a water-soluble vitamin, found naturally in a wide variety of animal foods (meats, fish, poultry, eggs, and dairy). Vitamin B12 helps convert food into glucose, which gives energy. Vitamin B12 increases the metabolism of fats and glucose, boosting energy production, which in turn decreases weight gain by muscle production and fat loss. It also helps in the production of red blood cells and DNA, as well as the proper functioning of the central nervous system. It promotes high levels of neurotransmitters such as serotonin and dopamine, preventing depression and emotional eating. 

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Effects of Chromium on Weight Reduction

Chromium Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Chromium is a low-dose mineral present in many foods (broccoli, potatoes, whole-grain products, beef, and poultry). Chromium Picolinate is the safest form of Chromium found in dietary supplements. It promotes the metabolism of carbohydrates and fats by enhancing the potency of the hormone insulin, which in turn controls the absorption of amino acids. Sufficient Chromium improves the lowering of blood sugar, preventing the risk of type 2 diabetes. Chromium also allows minerals to absorb better by surrounding it with neutral molecules, which allows passing into the cell membrane. 

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Effects of Fibersol on Weight Reduction

Fibersol Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Fibersol is a digestion-resistant maltodextrin and a low viscosity soluble dietary fiber (90%), drawn from corn starch by proprietary method. Fibersol’s molecular bonds are indigestible, allowing digestion-resistant maltodextrin to be a healthy replacement for sugar in most foods and beverages. Fibersol’s starch linkages remain in the digestive tract, which in turn increases satiety hormones such as peptide YY (PYY) and glucose-like peptide-1 (GLP-1). It boosts essential fibers to food while reducing caloric intake, resulting in fullness for a long period of time. Thus, Fibersol can delay hunger, and ultimately reduce weight. 

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WATER INTAKE Effect on Weight Reduction, Diabetes and Cravings in GLOBESITY Bootcamp for the Obese

Water Intake Effects on Weight Reduction, Cravings and Diabetes in Globesity Bootcamp for the Obese

The human body is composed of ~75% water, which plays an important role in every bodily function. Hydrated a person is more efficient in body performance ranging from thinking to burning body fat. Water intake aids in weight loss. It suppresses appetite, boosts metabolism, and makes exercise more effective. Drinking more water promotes satiation, as it passes through the system and stretches the stomach, resulting in fullness. Drinking water also stimulates heat production in the body, resulting in a higher rate of metabolism.

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Inulin Effects On Weight Reduction, Cravings And Diabetes in GLOBESITY Bootcamp for the Obese

Inulin Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Inulin is a soluble fiber found in 36,000 plant species (wheat, onion, banana, garlic, asparagus, etc.) and in some bacteria and fungi. The chicory roots are the richest source of inulin. Several manufactured forms of inulin are Chicory inulin and High-Performance (HP) inulin. In 2018 the FDA approved inulin as a dietary fiber component used to increase the nutritional value of processed food products in the United States. Inulin stimulates growth of beneficial bacteria, which in turn helps improve bowel function and gut health, curb appetite, and boosts immunity.

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Beta Glucan Effects On Weight Reduction, Cravings And Diabetes in GLOBESITY Bootcamp for the Obese

Beta Glucan Effects on Weight Reduction, Cravings and Diabetes in GLOBESITY Bootcamp for the Obese

Beta Glucan is a soluble dietary fiber found naturally in cereal grains, yeast, and in medicinal mushrooms (cordyceps, reishi, shitake, and maitake). Among its sources, barley has the highest Beta Glucan content. Beta Glucan is a polysaccharide that promotes good health by reducing cholesterol, and controls blood sugar levels. Beta Glucan lowers blood cholesterol by preventing the absorption of cholesterol from food in the stomach and intestines. If injected, Beta Glucan stimulates the immune system by growing chemicals which prevent infection. Beta Glucan also helps with constipation and bowel issues, preserves healthy intestinal bacteria, and helps regulate weight.

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Sleep Duration Effects on Weight Reduction, Cravings and Diabetes (by Don Juravin)

Sleep Duration Effects On Weight Reduction And Cravings In The GLOBESITY Bootcamp For The Obese

The GLOBESITY Bootcamp requires its members to sleep well for 8 hours per day during the weight loss procedure. Research shows that men and women consume 15.3% and 9.2% more calories, respectively, when deprived of sleep (from an average of 8 hours per night to 4 hours per night). For an average intake of 1,900 calories per day, this can lead to a weight gain of 250g to 500g (0.55 lb to 1 lb) per week, and 13 kg to 26 kg (28 lbs to 57 lbs) per year.

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Guar Gum Effects On Weight Reduction, Cravings And Diabetes in GLOBESITY Bootcamp for the Obese

Guar Gum Effects On Weight Reduction, Cravings And Diabetes in GLOBESITY Bootcamp for the Obese

Guar gum decreases body weight by 1.8 lbs (~0.81 kg) in overweight adults and those with additional risk factors for cardiovascular disease (Jovanovski 2020).
Guar gum increases satiety for 10 hours (Faris 1998).
Guar gum decreases daily energy intake by 310 calories (Pasman 1997b). That is a weight loss of ~2.5 kg (5.3 lbs) per month or 30 kg (66 lbs) per year.
Guar gum increases the ratio of the healthy to unhealthy gut flora by 100% to 1,000% (Fak 2015, Ohashi 2015, Berger 2014, Okubo 1994). An unhealthy microbiome promotes sugar cravings (Roberfroid 2010).

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